Description

Propafenone-D5 is a deuterium-labeled analog of the Class 1C antiarrhythmic drug, propafenone, where five hydrogen atoms are replaced with the stable isotope deuterium. This compound is of critical importance as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, clinical research organizations, and regulatory bodies requiring precise measurement of propafenone and its metabolites in biological matrices.

Application

• Primary use as an Internal Standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the quantification of propafenone.
• Critical component in Pharmacokinetic (PK) and Bioequivalence Studies to monitor drug concentration in plasma, serum, and other biological fluids.
• Facilitates Drug Metabolism and Disposition (DMPK) research, aiding in the identification and quantification of metabolites.
• Enhances data integrity in Clinical Trial sample analysis and Therapeutic Drug Monitoring (TDM) protocols.
• Used in the development and validation of robust analytical methods compliant with FDA, EMA, and ICH guidelines (e.g., ICH Q2(R1)).
• Supports forensic and toxicological analysis for the accurate determination of propafenone levels.

Basic Information

Product Name	Propafenone-D5
CAS No.	93909-48-9
Molecular Formula	C21H22D5NO3
Molecular Weight	~346.5 g/mol
Synonyms	1-[2-[2-Hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-1-propanone-d5; Propafenone (phenyl-d5); 2'-[2-Hydroxy-3-(propylamino)propoxy]-3-phenylpropiophenone-d5; (±)-Propafenone-d5; Propafenone D5; Propafenone (ring-d5); Rytmonorm-d5; SA 79-d5; Baxarytmon-d5
EINECS	Contact for details

Quality Control

Every batch of Propafenone-D5 is manufactured under strict quality systems and undergoes comprehensive analytical characterization to ensure identity, purity, and isotopic enrichment. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from NMR, HPLC, and mass spectrometry. We adhere to relevant industry standards for reference materials and can provide custom synthesis to meet specific purity or isotopic enrichment requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.