Description

DL-Methionine-3,3,4,4-D4 is a stable isotope-labeled analog of the essential amino acid methionine, where four hydrogen atoms are replaced by deuterium atoms at specific positions. This high-purity labeled compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by analytical chemists, pharmaceutical researchers, and life science professionals in metabolomics, proteomics, and drug development studies where internal standards of the highest isotopic and chemical purity are required.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a crucial quantitative reference in LC-MS and GC-MS analysis of methionine and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in stable isotope labeling studies to investigate methionine metabolism, transmethylation pathways, and homocysteine regulation in cell cultures and animal models.
• Pharmaceutical Research & Development: Employed in the development and validation of bioanalytical methods for new drug entities, ensuring accurate pharmacokinetic (PK) and pharmacodynamic (PD) data.
• Nutritional and Biomedical Research: Facilitates studies on protein synthesis, one-carbon metabolism, and the role of methionine in health, disease, and aging.
• Isotope Dilution Analysis: Provides the foundation for highly accurate and precise quantification of methionine levels in food science, clinical diagnostics, and environmental samples.

Basic Information

Product Name	DL-Methionine-3,3,4,4-D4
CAS No.	93709-61-6
Molecular Formula	C5H7D4NO2S
Molecular Weight	153.23 g/mol (for D4 labeled form)
Synonyms	(±)-2-Amino-4-(methyl-d3-sulfanyl)butanoic-3,3,4,4-d4 acid; Methionine-d4; DL-Methionine-d4; (RS)-Methionine-3,3,4,4-d4; 2-Amino-4-(methylsulfanyl)butanoic-3,3,4,4-d4 acid; (dl)-Methionine-3,3,4,4-d4; Methyl-d3-sulfanyl-d4-butanoic acid; Deuterated DL-Methionine
EINECS	Contact for details

Quality Control

Our DL-Methionine-3,3,4,4-D4 is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity, meeting the stringent requirements of analytical research. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic purity (atom % D), chemical purity (by HPLC), and confirmation of structure. We adhere to rigorous in-house quality standards to guarantee batch-to-batch consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which could affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.