Description

Ursodeoxycholic Acid Methyl Ester-D5 is a deuterium-labeled derivative of the methyl ester of ursodeoxycholic acid, a primary bile acid. This stable isotope-labeled compound is of critical importance for use as an internal standard in quantitative mass spectrometry-based analytical methods, ensuring high accuracy and precision in measurement. It is primarily required by pharmaceutical research and development laboratories, clinical diagnostic facilities, and analytical chemistry service providers engaged in metabolic studies, pharmacokinetic analysis, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for the accurate quantification of ursodeoxycholic acid and its metabolites in complex biological matrices like plasma, serum, and bile.
• Pharmacokinetic and Bioavailability Studies: Used in drug development to track the absorption, distribution, metabolism, and excretion (ADME) of ursodeoxycholic acid-based therapeutics.
• Clinical Diagnostic Assays: Supports the development and validation of high-sensitivity diagnostic tests for liver function and bile acid disorders.
• Metabolic Pathway Research: Aids in elucidating bile acid synthesis and enterohepatic circulation pathways in both healthy and disease states.
• Quality Control in Pharmaceutical Manufacturing: Serves as a reference standard for ensuring the purity and potency of active pharmaceutical ingredients (APIs) derived from bile acids.
• Stable Isotope Dilution Mass Spectrometry (SID-MS): The deuterium label (D5) provides the mass shift necessary for precise and interference-free quantification in this gold-standard technique.

Basic Information

Product Name	Ursodeoxycholic Acid Methyl Ester-D5
CAS No.	93701-19-0
Molecular Formula	C26H39D5O4
Molecular Weight	419.65 g/mol (approximate)
Synonyms	UDCA Methyl Ester-D5; Methyl Ursodeoxycholate-D5; 3α,7β-Dihydroxy-5β-cholan-24-oic Acid Methyl Ester-D5; Methyl 3α,7β-dihydroxy-5β-cholan-24-oate-D5; Ursodeoxycholic Acid-d5 Methyl Ester; Deuterated UDCA Methyl Ester; (3α,5β,7β)-3,7-Dihydroxycholan-24-oic Acid Methyl Ester-d5
EINECS	Contact for details

Quality Control

Every batch of Ursodeoxycholic Acid Methyl Ester-D5 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC assay, NMR for structural confirmation, and mass spectrometry for isotopic enrichment verification. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D5)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.