Description

N,n-Dimethyl-3-Trimethylsilyl-2-Propynamide is a specialized organosilicon building block featuring a unique combination of a protected terminal alkyne and an amide functional group. This compound is valued for its role as a versatile synthon in advanced organic synthesis, particularly for constructing complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring alkyne functionalization.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides where the trimethylsilyl-protected alkyne moiety is essential.
• Material Science Research: Serves as a precursor in the development of specialty polymers, dendrimers, and organic electronic materials.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Heck, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for catalysis and organometallic complexes.
• Academic & Industrial R&D: A valuable reagent for methodology development and exploring new synthetic pathways in organic chemistry.

Basic Information

Product Name	N,n-Dimethyl-3-Trimethylsilyl-2-Propynamide
CAS No.	93641-74-8
Molecular Formula	C9H19NOSi
Molecular Weight	185.34 g/mol
Synonyms	3-(Trimethylsilyl)-N,N-dimethyl-2-propynamide; N,N-Dimethyl-3-(trimethylsilyl)propiolamide; 2-Propynamide, N,N-dimethyl-3-(trimethylsilyl)-; TMS-Propargyl Dimethylamide; Dimethyl(3-trimethylsilyl-2-propynyl)amine; (Trimethylsilyl)propiolic Acid Dimethylamide; N,N-Dimethyl-3-trimethylsilylpropiolamide
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-3-Trimethylsilyl-2-Propynamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high purity and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.