Description

1H-Indene-1-Propanol, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-γ,7a-dimethyl-, [1R-[1α(R*),3aβ,4α,7aα]]- (9Ci) is a high-purity, stereochemically defined synthetic intermediate of significant value in advanced organic synthesis. This compound matters for its role as a key chiral building block in the development of complex, biologically active molecules, enabling precise control over molecular architecture. It is primarily needed by pharmaceutical R&D and fine chemical sectors for constructing novel therapeutic agents and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel active pharmaceutical ingredients (APIs), particularly for steroidal or terpenoid-based drug candidates.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce defined stereocenters into complex target molecules.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs targeting various disease pathways.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for potential drug candidates during late-stage development.
• Fine Chemical Production: Employed in the manufacture of high-value specialty chemicals, including fragrances, agrochemicals, and advanced materials.
• Academic & Institutional Research: A valuable reagent for methodological studies in organic synthesis and total synthesis of natural products.

Basic Information

Product Name	1H-Indene-1-Propanol, 4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]octahydro-γ,7a-dimethyl-, [1R-[1α(R*),3aβ,4α,7aα]]- (9Ci)
CAS No.	93489-70-4
Molecular Formula	C20H38O2Si
Molecular Weight	338.61 g/mol
Synonyms	4-[(tert-Butyldimethylsilyl)oxy]octahydro-γ,7a-dimethyl-1H-indene-1-propanol, [1R-[1α(R*),3aβ,4α,7aα]]-; (1R,3aS,4R,7aS)-4-[(tert-Butyldimethylsilyl)oxy]-1-[(1R)-1-hydroxypropyl]-octahydro-3a,7a-dimethyl-1H-indene; TBDMS-protected indanol propanol derivative; Chiral TBDMS-indanol propanol; Sterically hindered silyl ether alcohol; Advanced chiral building block.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. All materials are characterized using advanced analytical techniques including NMR, HPLC, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity, and impurity profile is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.