Description

Acetylcholine-D9 Bromide CAS NO 93449-32-2 is a stable isotope-labeled analog of the essential neurotransmitter acetylcholine, where nine hydrogen atoms are replaced by deuterium. This high-purity compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry-based research. It serves as an indispensable internal standard for scientists and quality control professionals in pharmaceutical development, clinical diagnostics, and advanced neurochemical research, where precise measurement of acetylcholine levels is paramount.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of endogenous acetylcholine in complex biological matrices like plasma, cerebrospinal fluid, and brain tissue homogenates.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Used in drug development to study the absorption, distribution, metabolism, and excretion of cholinergic drugs.
• Neurological Disorder Research: Essential for investigating acetylcholine dysregulation in conditions such as Alzheimer's disease, Parkinson's disease, and myasthenia gravis.
• Clinical Diagnostic Assays: Enables the development and validation of high-sensitivity diagnostic tests for cholinergic function.
• Metabolomics and Biomarker Discovery: Facilitates precise profiling of cholinergic metabolites in large-scale metabolomic studies.
• Quality Control in Pharmaceutical Manufacturing: Ensures batch-to-batch consistency and potency of cholinergic active pharmaceutical ingredients (APIs) and finished drug products.

Basic Information

Product Name	Acetylcholine-D9 Bromide
CAS No.	93449-32-2
Molecular Formula	C7D9BrNO2 *
Molecular Weight	224.12 g/mol (approx.) *
Synonyms	(2-Acetoxyethyl)trimethyl-d9-ammonium Bromide; Deuterated Acetylcholine Bromide; ACh-d9 Bromide; Acetylcholine (N,N,N-trimethyl-d9) Bromide; 2-(Acetyloxy)-N,N,N-trimethyl-d9-ethanaminium Bromide; (2-Acetyloxyethyl)trimethyl-d9-azanium Bromide; Acetylcholine-d9 (Bromide Salt); Acetylcholine-d9 Br
EINECS	Contact for details

* Calculated for the deuterated form. Contact us for the exact certificate of analysis.

Quality Control

Every batch of our Acetylcholine-D9 Bromide is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. Comprehensive Certificates of Analysis (COA) are provided, detailing parameters such as assay by HPLC, isotopic enrichment by NMR or MS, and impurity profiles. Our quality commitment ensures reliable and reproducible results in your most critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.