Description

Asperlicin E is a potent, non-peptidal cholecystokinin (CCK) antagonist derived from the fungus *Aspergillus alliaceus*. This compound is of significant interest in pharmaceutical research and development due to its high affinity and selectivity for the CCK-A receptor subtype. It serves as a critical research tool and a potential lead compound for developing therapeutic agents targeting gastrointestinal disorders, anxiety, and satiety. Researchers and developers in the pharmaceutical, biotechnology, and academic sectors require this high-purity biochemical for advanced studies and formulation development.

Application

• Pharmaceutical Research: As a reference standard and active pharmaceutical ingredient (API) in the development of novel CCK receptor antagonists.
• Neuropharmacology Studies: Investigation of cholecystokinin's role in anxiety, panic disorders, and nociception (pain perception).
• Gastrointestinal Drug Discovery: Research into therapies for conditions like irritable bowel syndrome (IBS), pancreatitis, and gastroparesis.
• Satiety and Obesity Research: Exploration of CCK's function in appetite regulation and the development of potential anti-obesity agents.
• Biochemical Assay Development: Used as a ligand in receptor binding assays and high-throughput screening (HTS) to identify new drug candidates.
• Academic & Institutional Research: Fundamental studies on receptor-ligand interactions and signal transduction pathways.

Basic Information

Product Name	Asperlicin E
CAS No.	93413-05-9
Molecular Formula	C33H33N3O6
Molecular Weight	567.63 g/mol
Synonyms	Asperlicin E; (-)-Asperlicin E; L-364,718; L364718; MK-329; Devazepide; 3S-(-)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide; 1,4-Benzodiazepine-3-carboxamide, N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-1H-indole-2-carboxamide, (3S)-
EINECS	Contact for details

Quality Control

Our Asperlicin E is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting key parameters such as assay, related substances, and residual solvents. For specific pharmacopeial standards (e.g., USP reference standard grade), please contact our technical support team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.