Description

5-Bromo-D-Tryptophan is a halogenated derivative of the essential amino acid tryptophan, featuring a bromine atom at the 5-position of the indole ring and the D-configuration. This specific stereochemistry and substitution pattern make it a valuable chiral building block and a key intermediate in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel bioactive compounds, including peptide-based therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new drug candidates, particularly in oncology and neurology.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate modified tryptophan residues, altering peptide stability and biological activity.
• Biochemical Research: Serves as a precursor or standard in metabolic pathway studies and enzyme inhibition assays.
• Proteomics & Labeling: Potential use as a heavy-atom labeled analog in X-ray crystallography or mass spectrometry for structural biology studies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	5-Bromo-D-Tryptophan
CAS No.	93299-40-2
Molecular Formula	C₁₁H₁₁BrN₂O₂
Molecular Weight	283.12 g/mol
Synonyms	D-5-Bromotryptophan; (R)-2-Amino-3-(5-bromo-1H-indol-3-yl)propanoic acid; 5-Bromo-D-tryptophan; 5-Bromotryptophan, D-; 5-Br-D-Trp; 5-Bromo-(R)-tryptophan; 5-Bromotryptophan D-form
EINECS	Contact for details

Quality Control

Our 5-Bromo-D-Tryptophan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) documenting identity, purity (typically ≥98% by HPLC), and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.