Description

Diethyl Acetamidomalonate-15N is a stable isotope-labeled derivative of diethyl acetamidomalonate, where the nitrogen atom is enriched with the 15N isotope. This compound serves as a crucial labeled building block for the synthesis of isotopically enriched amino acids, peptides, and other nitrogen-containing bioactive molecules. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science who require precise metabolic tracing, structural elucidation, or the development of labeled internal standards for analytical methods.

Application

• Pharmaceutical Research & Development: As a key precursor for the synthesis of 15N-labeled amino acids (e.g., glycine, alanine, aspartic acid) used in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical assays, and NMR-based structural biology.
• Proteomics and Metabolomics: Enables the production of isotopically labeled peptides and metabolic intermediates for use as internal standards in mass spectrometry (MS) for accurate quantification and pathway analysis.
• Agrochemical Development: Used in the synthesis of labeled herbicide or pesticide analogs to study environmental fate, degradation pathways, and residue analysis.
• Academic Research: A fundamental reagent in organic synthesis and mechanistic studies for investigating reaction pathways using 15N NMR spectroscopy.
• Diagnostic Agent Synthesis: Potential building block for creating labeled compounds used in medical imaging or diagnostic probes.

Basic Information

Product Name	Diethyl Acetamidomalonate-15N
CAS No.	92877-34-4
Molecular Formula	C9H15NO5 (15N)
Molecular Weight	217.22 g/mol (for 15N labeled form)
Synonyms	Diethyl (Acetylamino)malonate-15N; Diethyl 2-Acetamidomalonate-15N; Acetamidomalonic Acid Diethyl Ester-15N; Diethyl Acetamidomalonate (15N); Acetamidomalonic Ester-15N; Ethyl Acetamidomalonate-15N; 2-(Acetylamino)propanedioic Acid Diethyl Ester-15N; Diethyl N-Acetylaminomalonate-15N
EINECS	Contact for details

Quality Control

Every batch of Diethyl Acetamidomalonate-15N is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure product identity, purity, and isotopic enrichment meet the exacting requirements of research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including isotopic purity (15N atom %), chemical purity (by HPLC), and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (15N confirmed)
Purity (HPLC)	≥ 98.0%
Isotopic Purity (15N Atom %)	≥ 98% (Custom enrichments available)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.