Description

[S-(R*,R*)]-2-[2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1-Oxopropyl]-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Phenylmethyl is a high-purity, non-natural amino acid derivative and a key chiral building block in advanced organic synthesis. This compound is specifically engineered to provide exceptional stereochemical control and structural complexity for the development of novel bioactive molecules. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the synthesis of peptide-based therapeutics, enzyme inhibitors, and other pharmacologically active compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in protease inhibitor and peptidomimetic drug discovery programs.
• Peptide Synthesis: Used as a protected amino acid derivative in solid-phase and solution-phase peptide synthesis to introduce the tetrahydroisoquinoline carboxylic acid scaffold.
• Chemical Biology Research: Serves as a specialized building block for creating chemical probes, libraries for high-throughput screening, and tools to study protein-protein interactions.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Process Chemistry & Scale-Up: Provides a reliable, high-quality starting material for the optimization and commercial-scale manufacturing of target molecules.

Basic Information

Item	Detail
Product Name	[S-(R*,R*)]-2-[2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-1-Oxopropyl]-1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid Phenylmethyl
CAS No.	92829-12-4
Molecular Formula	C25H28N2O5
Molecular Weight	436.50 g/mol
Synonyms	Boc-D-Tic(3)-OH (Benzyl ester); (2S,3R)-1,2,3,4-Tetrahydro-2-[[(2S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxopropyl]amino]-3-isoquinolinecarboxylic Acid Phenylmethyl Ester; N-Boc-D-Tic(3)-OBzl; Benzyl (2S,3R)-2-[(2S)-2-[(tert-Butoxycarbonyl)amino]propanamido]-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; (2S,3R)-2-[(2S)-2-[(tert-Butoxycarbonylamino)propanoyl]amino]-3-(benzyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing purity, identity, and chiral purity is provided with each shipment. We support development and cGMP manufacturing needs with appropriate documentation and regulatory starting material classification support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.