Description

(S)-Nornicotine-D4 is a deuterium-labeled isotopologue of the tobacco alkaloid (S)-nornicotine, specifically designed for use as an internal standard in analytical chemistry. This compound is critical for ensuring the accuracy and precision of quantitative analyses, particularly in mass spectrometry, by correcting for variations in sample preparation and instrument response. It is an essential tool for researchers and quality control laboratories in the pharmaceutical, forensic, and tobacco science industries who require high-fidelity data for pharmacokinetic studies, metabolite profiling, and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Primary application for the accurate quantification of nornicotine and related alkaloids in complex biological matrices.
• Pharmacokinetic and Metabolic Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) research to track the fate of nicotine derivatives.
• Forensic and Clinical Toxicology: Enables precise measurement of nicotine metabolites in bodily fluids for exposure assessment and compliance monitoring.
• Tobacco Product Analysis: Supports the characterization and standardization of nicotine and minor alkaloid content in tobacco and next-generation nicotine products.
• Biochemical Research: Serves as a tracer in studies investigating nicotinic acetylcholine receptor interactions and neurotransmitter pathways.
• Reference Material for Certified Standards: Used in the development and calibration of certified reference materials (CRMs) for analytical laboratories.

Basic Information

Product Name	(S)-Nornicotine-D4
CAS No.	92761-98-3
Molecular Formula	C9H8D4N2
Molecular Weight	150.22 g/mol
Synonyms	(S)-2-(3-Pyrindinyl)-D4-pyrrolidine; (S)-Nornicotine-2,4,5,6-D4; (S)-1-Methyl-2-(3-pyridyl)-D4-pyrrolidine; (S)-N-Methyl-2-(3-pyridyl)-D4-pyrrolidine; (S)-3-(2-Pyrrolidinyl)-D4-pyridine; Deuterated (S)-Nornicotine; (S)-Nornicotine-d4; Pyrrolidine, 2-(3-pyridinyl)-, (2S)-, 2,4,5,6-tetradeuterio-
EINECS	Contact for details

Quality Control

Our (S)-Nornicotine-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. A detailed Certificate of Analysis (COA) is provided, documenting the assay, isotopic enrichment level, and limits for any impurities. We support compliance with GMP and ISO 17034 guidelines for reference material producers.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is easily oxidized (store under inert atmosphere). For long-term storage, keep under an inert gas (argon or nitrogen) in a freezer (-20°C). Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by GC)	≥ 95.0%
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.