Description

L-Leucine-D7 is a stable isotope-labeled analog of the essential amino acid L-Leucine, where seven hydrogen atoms are replaced by deuterium. This high-purity labeled compound is critical for advanced analytical and metabolic research, providing a reliable internal standard for precise quantification. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in mass spectrometry, metabolic pathway tracing, and drug development studies.

Application

• Mass Spectrometry Internal Standard: Serves as a critical reference compound for the accurate quantification of L-Leucine in complex biological matrices using LC-MS/MS and GC-MS.
• Metabolic Research & Flux Analysis: Used as a tracer to study protein synthesis, degradation rates, and amino acid metabolism in cell cultures, tissues, and whole organisms.
• Pharmaceutical R&D: Employed in the development and pharmacokinetic/pharmacodynamic (PK/PD) studies of new therapeutic agents, particularly those targeting metabolic pathways.
• Clinical Diagnostics: Facilitates the development of high-precision assays for inborn errors of metabolism, such as Maple Syrup Urine Disease (MSUD).
• Nutritional Science: Used in studies investigating amino acid requirements, absorption, and utilization in sports nutrition and clinical nutrition.
• Biomarker Discovery: Aids in the identification and validation of metabolic biomarkers for various disease states.

Basic Information

Product Name	L-Leucine-D7
CAS No.	92751-17-2
Molecular Formula	C6D7H6NO2
Molecular Weight	138.19 g/mol
Synonyms	(2S)-2-Amino-4-methyl-D7-pentanoic acid; (S)-2-Amino-4-methyl-D7-pentanoic acid; L-2-Amino-4-methyl-D7-pentanoic acid; Leucine-D7; (S)-Leucine-D7; Deuterated L-Leucine; L-Leucine (methyl-d7); L-Leucine-d7
EINECS	Contact for details

Quality Control

Our L-Leucine-D7 is manufactured under strict quality management systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and other critical parameters. We support compliance with cGMP and ISO 9001 standards for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Optical Rotation	+14.5° to +16.5° (c=2 in 6N HCl)
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.