Description

Methyl Tetraisopropylphosphorodiamidite is a specialized organophosphorus compound widely used as a key intermediate in organic synthesis. Its primary value lies in its role as a highly effective phosphitylating agent, crucial for the preparation of phosphoramidites and other nucleotide derivatives. This chemical is essential for research and production in the pharmaceutical and agrochemical industries, particularly in oligonucleotide synthesis for therapeutic and diagnostic applications.

Application

• Key Intermediate in Oligonucleotide Synthesis: Serves as a critical phosphitylating agent in the automated solid-phase synthesis of DNA and RNA strands for antisense therapeutics, siRNA, and PCR primers.
• Phosphoramidite Monomer Production: Used in the manufacture of nucleoside phosphoramidites, the building blocks for modern oligonucleotide synthesis.
• Pharmaceutical Research & Development: Employed in the synthesis of novel nucleotide-based drug candidates and prodrugs targeting various diseases.
• Agrochemical Synthesis: Acts as an intermediate in the creation of certain organophosphate-based active ingredients and plant growth regulators.
• Material Science: Utilized in the synthesis of specialized ligands for catalysis and in the development of phosphorus-containing polymers.
• Process Chemistry & Scale-Up: Provides a reliable and scalable route for the industrial production of nucleotide analogs and other phosphorus-containing fine chemicals.

Basic Information

Product Name	Methyl Tetraisopropylphosphorodiamidite
CAS No.	92611-10-4
Molecular Formula	C13H31N2OP
Molecular Weight	262.38 g/mol
Synonyms	Methyl N,N,N',N'-Tetraisopropylphosphorodiamidite; Methylbis(diisopropylamino)phosphine; P-Methyl-N,N,N',N'-tetraisopropylphosphorous diamide; Phosphorodiamidous acid, methyl-, bis(1-methylethyl) ester; Methyl Tetraisopropyl Phosphorodiamidite; (Diisopropylamino)methylphosphine bis(diisopropylamide); MTIPD
EINECS	Contact for details

Quality Control

Our Methyl Tetraisopropylphosphorodiamidite is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ³¹P) and HPLC analysis, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (argon or nitrogen) after opening. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
³¹P NMR Purity	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.