Description

1-Methyl-5-Trimethylsilanyl-1H-Pyrazole CAS NO 92524-99-7 is a specialized organosilicon-protected pyrazole derivative, serving as a versatile and valuable synthetic intermediate in advanced organic chemistry. Its core value lies in the trimethylsilyl (TMS) protecting group, which enhances solubility, alters reactivity, and provides a handle for selective deprotection in multi-step syntheses. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science sectors for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing functionalized pyrazole cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the pyrazole moiety is a critical pharmacophore.
• Ligand Precursor: Serves as a starting material for the preparation of N-heterocyclic carbene (NHC) ligands and other coordinating compounds in catalysis.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its modifiable structure.
• Cross-Coupling Reactions: Acts as a substrate or reagent in palladium-catalyzed cross-coupling reactions, such as Suzuki or Sonogashira couplings, after functional group manipulation.
• Protecting Group Strategy: The TMS group can be used to protect the nitrogen during synthetic sequences, allowing for selective reactions at other sites on the molecule.

Basic Information

Product Name	1-Methyl-5-Trimethylsilanyl-1H-Pyrazole
CAS No.	92524-99-7
Molecular Formula	C7H16N2Si
Molecular Weight	156.30 g/mol
Synonyms	5-(Trimethylsilyl)-1-methyl-1H-pyrazole; 1-Methyl-5-(trimethylsilyl)pyrazole; 1-Methyl-5-(trimethylsilyl)-1H-pyrazole; 1H-Pyrazole, 1-methyl-5-(trimethylsilyl)-; 5-Trimethylsilyl-1-methylpyrazole; TMS-Pyrazole derivative; N-Methyl-5-trimethylsilylpyrazole
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-Trimethylsilanyl-1H-Pyrazole is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.