Description

tert-Butyl(4-Iodobutoxy)dimethylsilane is a specialized organosilicon reagent featuring a reactive iodoalkyl chain protected by a bulky tert-butyldimethylsilyl (TBDMS) group. This unique bifunctional structure makes it a valuable intermediate for the controlled synthesis and functionalization of complex organic molecules, particularly in pharmaceutical and advanced materials research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, agrochemical, and life sciences industries for constructing carbon chains and introducing silicon-based protecting groups.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing alkyl linkers or as a precursor for further functionalization.
• Organic Synthesis Reagent: Used in nucleophilic substitution reactions, cross-coupling reactions (e.g., with Grignard or organozinc reagents), and as a protected hydroxyl equivalent in multi-step syntheses.
• Polymer & Material Science: Serves as a monomer or modifier for creating functionalized silicones, dendrimers, or surface coatings with specific organic side chains.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for metal catalysis or as a component in organocatalysts.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides, fungicides, or plant growth regulators requiring specific silicon-containing alkyl structures.
• Protecting Group Chemistry: The TBDMS group is used to protect alcohols; this compound allows for the simultaneous introduction of a protected alcohol and a reactive iodide for further chain elongation.

Basic Information

Product Name	tert-Butyl(4-Iodobutoxy)dimethylsilane
CAS No.	92511-12-1
Molecular Formula	C10H23IOSi
Molecular Weight	314.29 g/mol
Synonyms	4-(tert-Butyldimethylsilyloxy)-1-iodobutane; 1-Iodo-4-[(tert-butyldimethylsilyl)oxy]butane; 4-Iodobutyl tert-butyldimethylsilyl ether; (4-Iodobutoxy)(tert-butyl)dimethylsilane; TBDMS-4-iodobutyl ether; tert-Butyldimethyl(4-iodobutoxy)silane; Silane, tert-butyl(4-iodobutoxy)dimethyl-; DTXSID60667691
EINECS	Contact for details

Quality Control

Our tert-Butyl(4-Iodobutoxy)dimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.