Description

Bis(2,2,2-Trifluoroethyl) Phosphite is a specialized organophosphorus compound characterized by its trifluoroethoxy substituents, which impart unique reactivity and stability. This chemical serves as a crucial intermediate and ligand in advanced synthetic chemistry, particularly valued for its role in facilitating challenging transformations. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where its phosphite moiety acts as a precursor or ligand in catalytic processes.
• Ligand for Catalysis: Functions as a ligand in transition metal-catalyzed reactions, including cross-coupling and hydrogenation, due to its electron-withdrawing trifluoroethyl groups.
• Polymer Modification: Employed as a stabilizer or modifying agent in high-performance polymers and resins to improve thermal and chemical resistance.
• Flame Retardant Precursor: Serves as an intermediate in the synthesis of phosphorus-based flame retardant additives for electronic and construction materials.
• Organic Synthesis Reagent: Utilized in laboratories for the preparation of other organophosphorus compounds, such as phosphonates and phosphates, via oxidation or other functional group interconversions.

Basic Information

Product Name	Bis(2,2,2-Trifluoroethyl) Phosphite
CAS No.	92466-70-1
Molecular Formula	C4H4F6O3P
Molecular Weight	236.04 g/mol
Synonyms	Phosphorous Acid Bis(2,2,2-trifluoroethyl) Ester; Di(2,2,2-Trifluoroethyl) Phosphite; 2,2,2-Trifluoroethyl Phosphite (dimer); Bis(trifluoroethoxy)phosphine Oxide (common misnomer); H-phosphonate Di(trifluoroethyl) Ester; P,P-Bis(2,2,2-trifluoroethyl) Hydrogen Phosphonite; EINECS 402-800-6
EINECS	402-800-6

Quality Control

Our production of Bis(2,2,2-Trifluoroethyl) Phosphite adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, NMR, and titration to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all critical specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 15-25°C under an inert atmosphere (e.g., nitrogen or argon), as the compound is easily oxidized. Keep away from strong bases and incompatible materials. For long-term storage, consider refrigeration at 2-8°C to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Acidity (Titration)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.