Description

3,6,14-Trihydroxy-6-(2-Carboxyallyl)-17-(Cyclopropylmethyl)Morphinan γ-Lactone 4,5-Epoxide is a high-purity, structurally complex chemical intermediate of significant interest in advanced pharmaceutical research and development. Its core value lies in its role as a key synthetic precursor for the development of novel opioid receptor ligands and other specialized therapeutic agents. This compound is essential for research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on neuropharmacology and analgesic drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel opioid analgesics and antagonists.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new central nervous system (CNS) active compounds.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Drug Development: Employed in the early-stage development of potential therapeutics targeting pain management.
• Academic Research: Utilized in university and institutional labs for biochemical and pharmacological studies of morphinan derivatives.
• Process Chemistry: Acts as a starting material or intermediate for scaling up synthetic routes under GMP or non-GMP conditions.

Basic Information

Product Name	3,6,14-Trihydroxy-6-(2-Carboxyallyl)-17-(Cyclopropylmethyl)Morphinan γ-Lactone 4,5-Epoxide
CAS No.	92398-20-4
Molecular Formula	C24H27NO7
Molecular Weight	441.48 g/mol
Synonyms	Norfentanyl Impurity; 17-Cyclopropylmethyl-3,6,14-trihydroxy-4,5-epoxy-6-(2-carboxyallyl)morphinan-γ-lactone; 4,5α-Epoxy-3,6α,14-trihydroxy-6β-[(2-carboxy-2-propen-1-yl)]-17-(cyclopropylmethyl)morphinan-7,8-lactone; Buprenorphine Related Compound; Buprenorphine Intermediate; 92398-20-4; Norfentanyl EP Impurity C
EINECS	Contact for details

Quality Control

Our 3,6,14-Trihydroxy-6-(2-Carboxyallyl)-17-(Cyclopropylmethyl)Morphinan γ-Lactone 4,5-Epoxide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material suitable for use as a pharmaceutical reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.