Description

2-[5-[Bis(2-Chloroethyl)Amino]-1H-Indol-3-Yl]Acetic Acid is a specialized nitrogen mustard derivative of indole-3-acetic acid, serving as a critical advanced pharmaceutical intermediate. Its molecular architecture, featuring a bis(2-chloroethyl)amino group, makes it a valuable precursor for the synthesis of targeted alkylating agents and prodrugs in oncology research. This compound is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing novel chemotherapeutic and targeted cancer therapies.

Application

• Key intermediate in the research and development of novel alkylating chemotherapeutic agents.
• Precursor for the synthesis of targeted prodrugs and antibody-drug conjugates (ADCs) in oncology.
• Building block for pharmacological research compounds targeting DNA replication.
• Used in academic and industrial research to study structure-activity relationships (SAR) of nitrogen mustards.
• Starting material for the preparation of experimental anti-cancer molecules and their analogs.
• Reference standard in analytical method development and quality control for related APIs.

Basic Information

Product Name	2-[5-[Bis(2-Chloroethyl)Amino]-1H-Indol-3-Yl]Acetic Acid
CAS No.	92298-15-2
Molecular Formula	C₁₄H₁₆Cl₂N₂O₂
Molecular Weight	315.20 g/mol
Synonyms	5-[Bis(2-chloroethyl)amino]indole-3-acetic acid; 2-{5-[Bis(2-chloroethyl)amino]-1H-indol-3-yl}acetic acid; 1H-Indole-3-acetic acid, 5-[bis(2-chloroethyl)amino]-; NSC 341964; Nitrogen mustard indole-3-acetic acid derivative; 5-(Bis(2-chloroethyl)amino)indol-3-ylacetic acid
EINECS	Contact for details

Quality Control

Every batch of 2-[5-[Bis(2-Chloroethyl)Amino]-1H-Indol-3-Yl]Acetic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.