Description

(S)-n-(2,5-Dioxotetrahydrofuran-3-Yl)-2-Phenoxyacetamide is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its specific stereochemistry and functional groups, which make it a critical precursor for constructing complex molecules with defined biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including potential enzyme inhibitors and receptor modulators.
• Peptidomimetic Synthesis: Used in the construction of peptide analogs and mimetics due to its dioxotetrahydrofuran moiety, which can mimic peptide bonds or serve as a constrained scaffold.
• Asymmetric Synthesis: Employed as a building block in stereoselective reactions to introduce the (S)-configuration into target molecules, crucial for drug efficacy and safety.
• Protease Inhibitor Research: Serves as a core structure or intermediate in the design of compounds targeting proteolytic enzymes.
• Chemical Biology Probes: Utilized in the synthesis of labeled or tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific compounds under cGMP conditions.

Basic Information

Product Name	(S)-n-(2,5-Dioxotetrahydrofuran-3-Yl)-2-Phenoxyacetamide
CAS No.	91807-59-9
Molecular Formula	C12H11NO5
Molecular Weight	249.22 g/mol
Synonyms	(S)-3-(2-Phenoxyacetamido)dihydrofuran-2,5-dione; (S)-N-(2,5-Dioxooxolan-3-yl)-2-phenoxyacetamide; (S)-3-(Phenoxyacetamido)tetrahydrofuran-2,5-dione; L-3-(Phenoxyacetamido)succinimide; (S)-Succinimide-3-phenoxyacetamide; (3S)-3-[(2-Phenoxyacetyl)amino]oxolane-2,5-dione; (S)-N-(2,5-Dioxotetrahydro-3-furanyl)-2-phenoxyacetamide
EINECS	Contact for details

Quality Control

Our (S)-n-(2,5-Dioxotetrahydrofuran-3-Yl)-2-Phenoxyacetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.