Description

Glycine, n-Benzoyl-, Labeled With Deuterium (9Ci) is a stable isotope-labeled derivative of N-benzoylglycine (hippuric acid), where nine carbon atoms are replaced with the deuterium isotope. This compound is a critical tool for advanced analytical research, enabling precise quantification and metabolic pathway tracing through mass spectrometry and NMR spectroscopy. It is essential for scientists in pharmaceutical development, clinical diagnostics, and biochemical research who require high-fidelity internal standards for accurate and reliable data.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative reference standard in LC-MS and GC-MS analysis of hippuric acid and related metabolites in biological matrices.
• Metabolic Pathway Tracing: Employed in deuterium-labeling studies to investigate the metabolism of glycine and benzoic acid derivatives in vivo and in vitro.
• NMR Spectroscopy: Serves as a valuable probe in nuclear magnetic resonance studies due to the distinct spectral properties of deuterium, aiding in structural elucidation and dynamic analysis.
• Pharmaceutical Research & Development: Facilitates drug metabolism and pharmacokinetics (DMPK) studies for compounds metabolized through glycine conjugation pathways.
• Clinical Diagnostic Assays: Enhances the accuracy of diagnostic tests measuring hippuric acid as a biomarker for toluene exposure or certain metabolic disorders.
• Biochemical Research: Used in enzymatic studies of glycine N-acyltransferase activity and the biosynthesis of hippurate.

Basic Information

Product Name	Glycine, n-Benzoyl-, Labeled With Deuterium (9Ci)
CAS No.	91787-63-2
Molecular Formula	C9D9HNO3
Molecular Weight	188.23 g/mol (for fully labeled form)
Synonyms	N-Benzoylglycine-d9; Hippuric Acid-d9; (Carboxymethyl-d2)amino-d2-d5-benzoate; Benzoylaminoacetic Acid-d9; Benzoylglycine-d9; Deuterated Hippuric Acid; Hippuric-d9 Acid; 2-(Benzoylamino)acetic-2,2-d2 acid-d7
EINECS	Contact for details

Quality Control

Every batch of our deuterium-labeled compounds is produced and analyzed under strict quality protocols to ensure isotopic purity and chemical integrity. Standard quality checks include determination of isotopic enrichment by NMR and MS, chemical purity by HPLC, and confirmation of structure. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (atom % D), chemical purity, and analytical methods is provided with each shipment to support your research compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (Atom % D)	≥ 98% (by 1H NMR/MS)
Chemical Purity (HPLC)	≥ 98.0%
Deuterium Content	Min. 9 atoms D
Solubility	Soluble in most polar organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.