Description

6-Chloro-3-((dimethylamino)methylene)indolin-2-one is a high-purity advanced pharmaceutical intermediate characterized by its unique oxindole scaffold. This compound matters as a critical building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors and other targeted therapeutics. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel kinase inhibitors and other small-molecule drug candidates targeting various disease pathways.
• Organic Synthesis Building Block: Utilized in medicinal chemistry for constructing complex heterocyclic frameworks, particularly functionalized oxindoles and spirocyclic compounds.
• Research & Development: Serves as a crucial reagent in academic and industrial R&D labs for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Used in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.

Basic Information

Product Name	6-Chloro-3-((dimethylamino)methylene)indolin-2-one
CAS No.	91505-83-8
Molecular Formula	C12H11ClN2O
Molecular Weight	234.68 g/mol
Synonyms	6-Chloro-3-[(dimethylamino)methylidene]-1,3-dihydro-2H-indol-2-one; 6-Chloro-3-(dimethylaminomethylene)oxindole; 2H-Indol-2-one, 6-chloro-3-[(dimethylamino)methylene]-1,3-dihydro-; 6-Chloro-3-(dimethylaminomethylene)-2-indolinone; 6-Chloro-3-(N,N-dimethylaminomethylene)indolin-2-one; 6-Chloro-3-(dimethylaminomethylene)indolin-2-one; (6-Chloro-2-oxo-2,3-dihydro-1H-indol-3-ylidene)-N,N-dimethylmethanamine
EINECS	Contact for details

Quality Control

Our 6-Chloro-3-((dimethylamino)methylene)indolin-2-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.