Description

Demethoxybuprenorphine is a high-purity synthetic opioid derivative and a key intermediate in advanced pharmaceutical research. This compound is of significant interest for its role in the development and analytical profiling of novel analgesic and addiction treatment medications. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and analytical service providers engaged in neuropharmacology and controlled substance studies.

Application

• Pharmaceutical Reference Standard: Serves as a critical certified reference material (CRM) for the qualitative and quantitative analysis of buprenorphine analogs in forensic and clinical toxicology.
• Metabolite Research: Used in the study of buprenorphine metabolism and pharmacokinetics to understand drug interactions and clearance pathways.
• Medicinal Chemistry Intermediate: Acts as a key synthetic building block for the research and development of new opioid receptor ligands with potential therapeutic applications.
• Analytical Method Development: Employed to validate and calibrate analytical methods such as HPLC, LC-MS/MS, and GC-MS for the detection of opioids in complex matrices.
• Pharmacological Studies: Utilized in in vitro and in vivo research to investigate structure-activity relationships (SAR) at opioid receptors.
• Impurity Profiling: Essential for identifying and quantifying process-related impurities and degradation products in buprenorphine API manufacturing.

Basic Information

Product Name	Demethoxybuprenorphine
CAS No.	91423-89-1
Molecular Formula	C28H37NO4
Molecular Weight	451.60 g/mol
Synonyms	21-Dehydroxy-21-methoxybuprenorphine; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (5α,7α); Buprenorphine Impurity F; Nor-Buprenorphine-3-methyl ether; 2'-O-Methylbuprenorphine
EINECS	Contact for details

Quality Control

Our Demethoxybuprenorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by validated chromatographic methods (HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.