Description

3-Amino-5-(4-Nitrophenyl)Thiophene-2-Carboxylic Acid Methyl Ester is a high-value, multifunctional heterocyclic building block characterized by its amino, nitro, and ester functional groups. This compound matters for its versatility as a key intermediate in the synthesis of complex organic molecules, particularly in the development of advanced materials and active pharmaceutical ingredients (APIs). Industries such as pharmaceutical R&D, agrochemical manufacturing, and specialty chemical synthesis rely on this precise chemical for constructing novel thiophene-based derivatives.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Serves as a building block for developing new generation pesticides and herbicides with thiophene cores for enhanced efficacy.
• Organic Electronic Materials: Used in research for constructing π-conjugated systems and charge-transport materials for applications in OLEDs and organic photovoltaics.
• Dye and Pigment Chemistry: Acts as an intermediate for synthesizing specialized dyes and pigments due to its nitro and amino groups, which influence color and lightfastness properties.
• Ligand and Catalyst Development: The amino and ester functionalities make it a useful starting point for creating novel ligands for metal catalysis in asymmetric synthesis.
• Academic and Industrial R&D: A valuable reagent for methodological studies in heterocyclic chemistry and the exploration of new chemical spaces.

Basic Information

Product Name	3-Amino-5-(4-Nitrophenyl)Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	91076-99-2
Molecular Formula	C12H10N2O4S
Molecular Weight	278.29 g/mol
Synonyms	Methyl 3-Amino-5-(4-nitrophenyl)thiophene-2-carboxylate; 3-Amino-5-(p-nitrophenyl)thiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 3-amino-5-(4-nitrophenyl)-, methyl ester; Methyl 3-amino-5-(4-nitrophenyl)-2-thiophenecarboxylate; 91076-99-2; 3-Amino-5-(4-nitrophenyl)-2-thiophenecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Amino-5-(4-Nitrophenyl)Thiophene-2-Carboxylic Acid Methyl Ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.