Description

L-n-Tau-Methyl-D3-Histidine is a stable isotope-labeled analog of the naturally occurring amino acid derivative. This compound is of critical importance for research requiring precise metabolic and pharmacokinetic tracing, offering unmatched specificity and reliability in analytical applications. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and analytical laboratories engaged in advanced mass spectrometry, biomarker discovery, and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical quantitative reference standard in bioanalytical method development and validation for histidine-related metabolites.
• Metabolic Pathway Tracing: Used in stable isotope labeling studies to investigate histidine metabolism, protein synthesis, and related biochemical pathways in vivo and in vitro.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Enables accurate quantification of drug candidates and their metabolites in complex biological matrices.
• Biomarker Discovery and Validation: Facilitates the precise measurement of potential disease biomarkers in clinical and preclinical samples.
• Nutritional and Sports Science Research: Applied in studies examining muscle protein synthesis, recovery, and the metabolic fate of amino acid supplements.
• Synthesis of Labeled Peptides/Proteins: Acts as a building block for the synthesis of deuterium-labeled peptides used as internal standards in proteomics.

Basic Information

Product Name	L-n-Tau-Methyl-D3-Histidine
CAS No.	91037-48-8
Molecular Formula	C10H14D3N3O3S
Molecular Weight	256.31 g/mol
Synonyms	L-N(τ)-Methyl-D3-histidine; (2S)-2-Amino-3-[1-methyl-4-(2H3)methyl-1H-imidazol-5-yl]propanoic acid; Deuterated L-1-Methylhistidine; Tau-Methyl-D3-L-histidine; 1-Methyl-D3-L-histidine; L-1-Methylhistidine (methyl-D3); 3-Methyl-D3-L-histidine; Stable Isotope Labeled Histidine Derivative
EINECS	Contact for details

Quality Control

Our L-n-Tau-Methyl-D3-Histidine is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as assay, isotopic enrichment, and impurity profile. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.