Description

1-o-Hexadecyl-2-o-Acetyl-Sn-Glyceryl-3-Phosphoryl-n-Methyl-Pyrrolidinium Ethanol is a high-purity synthetic phospholipid derivative, a key building block in advanced pharmaceutical and biochemical research. This compound is valued for its role in the formulation of novel drug delivery systems, particularly in creating stable, targeted liposomal and micellar structures. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors developing next-generation therapeutics and diagnostic agents.

Application

• Liposome and Nanoparticle Formulation: A critical cationic lipid component for constructing stable, positively charged liposomes used in mRNA, siRNA, and DNA delivery (non-viral gene therapy vectors).
• Drug Delivery Systems: Serves as a functional excipient to enhance cellular uptake and improve the bioavailability of poorly soluble active pharmaceutical ingredients (APIs).
• Biomimetic Membrane Research: Used in model membrane systems (e.g., lipid bilayers) to study cell membrane interactions, fusion processes, and protein-lipid dynamics.
• Diagnostic Agent Carrier: Employed in the development of contrast agents and probes for advanced imaging techniques such as MRI and fluorescence imaging.
• Transfection Reagent Synthesis: A key raw material in the manufacture of proprietary cationic lipid-based transfection reagents for in vitro and in vivo applications.
• Cosmetic Actives Delivery: Utilized in high-end cosmetic formulations to create nanocarriers for the targeted and sustained release of active compounds.

Basic Information

Product Name	1-o-Hexadecyl-2-o-Acetyl-Sn-Glyceryl-3-Phosphoryl-n-Methyl-Pyrrolidinium Ethanol
CAS No.	91021-63-5
Molecular Formula	C29H58NO7P
Molecular Weight	563.75 g/mol
Synonyms	1-Hexadecyl-2-acetyl-sn-glycero-3-phospho-N-methylethanolamine; Cationic Lipid 1; N-Methyl-1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine analog; 1-Cetyl-2-acetyl phosphatidyl-N-methylethanolamine; 16:0 Acetyl PG-N-ME; Phospholipid derivative 91021-63-5; DPPE-N-Methyl analog; N-Methyl-DPPE Acetylated
EINECS	Contact for details

Quality Control

Our 1-o-Hexadecyl-2-o-Acetyl-Sn-Glyceryl-3-Phosphoryl-n-Methyl-Pyrrolidinium Ethanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation and residual solvent analysis, to ensure it meets exacting standards for research and cGMP-guided applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.