Description

n-Acetyl-D3-5-Methoxytryptamine is a deuterated analog of melatonin, featuring three deuterium atoms at the acetyl group, which enhances its metabolic stability for research applications. This compound is a critical stable isotope-labeled internal standard used in quantitative analytical methods such as LC-MS/MS, ensuring precise and accurate measurement of its non-deuterated counterpart in complex matrices. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and CROs (Contract Research Organizations) engaged in pharmacokinetic studies, bioanalytical method development, and drug metabolism research.

Application

• Primary use as a stable isotope-labeled internal standard for the quantification of melatonin and related tryptamines in biological samples via mass spectrometry.
• Essential for bioanalytical method development and validation in pharmaceutical research and clinical trials.
• Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) studies by providing a reliable reference for drug concentration analysis.
• Used in metabolomics and biomarker discovery research to study sleep-related metabolic pathways.
• Supports forensic and toxicological analysis for the accurate detection of tryptamine derivatives.
• Applied in academic research investigating the role of melatonin in circadian rhythms and neurochemistry.

Basic Information

Product Name	n-Acetyl-D3-5-Methoxytryptamine
CAS No.	90735-69-6
Molecular Formula	C₁₃H₁₃D₃N₂O₂
Molecular Weight	235.29 g/mol
Synonyms	Deuterated Melatonin-d3; N-Acetyl-5-methoxy-D3-tryptamine; Melatonin-d3 (acetyl-D3); N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]-2,2,2-trideuteroacetamide; 2,2,2-Trideutero-N-[2-(5-methoxy-1H-indol-3-yl)ethyl]acetamide; Acetyl-d3-5-methoxytryptamine; d3-Melatonin; Internal Standard for Melatonin
EINECS	Contact for details

Quality Control

Our n-Acetyl-D3-5-Methoxytryptamine is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and impurity profiles. We ensure compliance with relevant industry guidelines for reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.