Description

1-Chloro-5-Hydroxyisoquinoline is a versatile and high-value heterocyclic building block, primarily utilized in advanced organic synthesis. Its unique molecular structure, featuring both chloro and hydroxy substituents on the isoquinoline scaffold, makes it a critical intermediate for constructing complex pharmacophores. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it serves as a precursor for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its heterocyclic core for bioactivity.
• Material Science Research: Serves as a building block for creating organic ligands, dyes, and functional materials with specific optical or electronic properties.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploratory chemistry projects.
• Chemical Library Development: A valuable component for constructing diverse screening libraries in high-throughput drug discovery campaigns.

Basic Information

Product Name	1-Chloro-5-Hydroxyisoquinoline
CAS No.	90224-96-7
Molecular Formula	C9H6ClNO
Molecular Weight	179.60 g/mol
Synonyms	5-Hydroxy-1-chloroisoquinoline; 1-Chloro-5-isoquinolinol; Isoquinoline, 1-chloro-5-hydroxy-; 1-Chloro-5-hydroxy-isoquinoline; 90224-96-7
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Hydroxyisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.