Description

H-D-Glu(Obzl)-Otbu Hcl is a protected amino acid derivative, specifically a hydrochloride salt of a benzyl- and tert-butyl-protected glutamic acid enantiomer. This compound is a crucial high-purity building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing therapeutic peptides, diagnostic agents, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: Key raw material in the solid-phase and solution-phase synthesis of therapeutic peptides targeting metabolic and neurological disorders.
• Peptidomimetic Research: Serves as a critical scaffold for designing and synthesizing non-natural peptide analogs with enhanced stability and bioavailability.
• Bioconjugation: Used in the preparation of peptide-protein conjugates for antibody-drug conjugates (ADCs) and diagnostic imaging probes.
• Chemical Biology: Essential tool compound for studying enzyme-substrate interactions and protease activity in biochemical assays.
• Academic & Institutional Research: Employed in university and government labs for fundamental research in peptide chemistry and medicinal chemistry.
• Custom Synthesis: A starting point for contract research organizations (CROs) and CDMOs producing custom peptides for client projects.

Basic Information

Product Name	H-D-Glu(Obzl)-Otbu Hcl
CAS No.	90159-60-7
Molecular Formula	C₁₆H₂₄ClNO₄
Molecular Weight	329.82 g/mol
Synonyms	H-D-Glu(OBzl)-OtBu hydrochloride; (2R)-2-[(tert-Butoxy)carbonylamino]-5-(benzyloxy)-5-oxopentanoic acid hydrochloride; D-Glutamic acid, 5-benzyl ester, N-(tert-butoxycarbonyl)-, hydrochloride; Boc-D-Glu(OBzl)-OH hydrochloride; N-Boc-D-glutamic acid 5-benzyl ester hydrochloride; N-(tert-Butoxycarbonyl)-D-glutamic acid γ-benzyl ester hydrochloride; Boc-D-Glu(OBzl)-OtBu HCl; 90159-60-7
EINECS	Contact for details

Quality Control

Our H-D-Glu(Obzl)-Otbu Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and optical rotation to ensure identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all specifications and test results to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰/D: Specific range provided on COA
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.