Description

5-Difluoromethoxy-2-Mercapto-1H-Benzimidazole is a high-purity, advanced pharmaceutical intermediate characterized by its unique benzimidazole core functionalized with difluoromethoxy and mercapto groups. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for applications requiring enhanced metabolic stability and bioavailability. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and agrochemical industries for developing next-generation therapeutics and crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of proton pump inhibitors (PPIs) and other benzimidazole-based drug candidates.
• Agrochemical Synthesis: Used in the research and development of modern fungicides and herbicides that leverage the benzimidazole scaffold.
• Chemical Research: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Investigated as a monomer or additive for creating specialized polymers with unique electronic or thermal properties.

Basic Information

Product Name	5-Difluoromethoxy-2-Mercapto-1H-Benzimidazole
CAS No.	9763-62-7
Molecular Formula	C8H6F2N2OS
Molecular Weight	216.21 g/mol
Synonyms	2-Mercapto-5-(difluoromethoxy)-1H-benzimidazole; 5-(Difluoromethoxy)-1H-benzimidazole-2-thiol; 2-Mercapto-5-difluoromethoxybenzimidazole; 1H-Benzimidazole-2-thiol, 5-(difluoromethoxy)-; DFM-BIM; 9763-62-7; 5-DFMO-2-MBI
EINECS	Contact for details

Quality Control

Our 5-Difluoromethoxy-2-Mercapto-1H-Benzimidazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.