Description

Hydroxypropyl Methylcellulose Phthalate (HPMCP) is a versatile cellulose-based polymer derivative, widely recognized as an effective enteric coating agent. Its primary value lies in its pH-dependent solubility, ensuring targeted drug release in the intestinal tract while protecting active ingredients from gastric acid. This makes it a critical excipient for pharmaceutical manufacturers developing oral solid dosage forms. Industries requiring precise, delayed-release formulations, particularly in pharmaceuticals and advanced nutraceuticals, rely on its consistent performance and safety profile.

Application

• Enteric Coating for Tablets and Capsules: Provides a protective barrier that is insoluble in gastric fluid but dissolves readily in the higher pH environment of the small intestine.
• Controlled-Release Drug Delivery Systems: Used as a matrix former or coating to modulate the release rate of active pharmaceutical ingredients (APIs).
• Microencapsulation: Protects sensitive ingredients (e.g., probiotics, enzymes, oils) from moisture, oxygen, and stomach acid.
• Taste Masking: Effectively coats bitter or unpleasant-tasting drugs to improve patient compliance.
• Film-Forming Agent: Employed in the production of oral thin films and other specialty dosage forms.
• Pharmaceutical Granulation: Acts as a binder in wet granulation processes for improved flow and compaction properties.

Basic Information

Product Name	Hydroxypropyl Methylcellulose Phthalate
CAS No.	9050-31-1
Molecular Formula	(C6H7O2(OR)1(OR')2)n where R = -CH3, -CH2CH(OH)CH3; R' = -COC6H4COOH
Molecular Weight	Variable polymer (20,000 - 200,000 Da typical)
Synonyms	HPMCP; Hypromellose Phthalate; Hydroxypropylmethylcellulose Phthalate; Cellulose, Hydrogen Phthalate, Hydroxypropyl Methyl Ether; HP-55; HP-50; Shin-Etsu AQOAT; Pharmacoat HP
EINECS	Contact for details

Quality Control

Our Hydroxypropyl Methylcellulose Phthalate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with major pharmacopoeial standards, including USP-NF, Ph. Eur., and JP. Key parameters such as phthalyl content, viscosity, and degree of substitution are rigorously controlled. A comprehensive Certificate of Analysis (COA), detailing all test results against specification, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the storage area must have low humidity to prevent caking and hydrolysis. Keep away from strong acids, bases, and excessive heat.

Specification

Item	Specification
Appearance	White to off-white powder or granules
Identification (IR)	Conforms
Viscosity (2% solution)	3.0 - 15.0 mPa·s (cP)
Phthalyl Content	20.0 - 35.0 %
Methoxy Content	18.0 - 24.0 %
Hydroxypropoxy Content	5.0 - 12.0 %
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Heavy Metals	≤ 10 ppm
Assay (Titration)	95.0 - 102.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.