Description

Eudragit RL is a high-quality, cationic copolymer of ethyl acrylate, methyl methacrylate, and a low content of methacrylic acid ester with quaternary ammonium groups. This unique composition provides a pH-independent, sustained-release mechanism crucial for advanced pharmaceutical formulation. It is an essential excipient for manufacturers developing controlled-release solid oral dosage forms, such as tablets and pellets, where precise drug delivery is required.

Application

• Sustained-Release Tablet Coating: Primary application for creating water-insoluble, pH-independent, and permeable film coatings that control the diffusion of active pharmaceutical ingredients (APIs).
• Matrix Tablet Formulation: Used as a release-retarding agent in matrix systems for extended drug release profiles.
• Pellet and Granule Coating: Enables the functional coating of multi-particulate dosage forms for tailored release kinetics.
• Combination with Eudragit RS: Often blended with Eudragit RS to fine-tune the permeability and mechanical properties of the final film for specific release targets.
• Pharmaceutical Research & Development: A key polymer for pre-formulation studies and the development of novel controlled-release drug delivery systems.

Basic Information

Product Name	Eudragit RL
CAS No.	51822-44-7
Molecular Formula	(C5H8O2)x·(C4H6O2)y·(C7H14NO2)z
Molecular Weight	~150,000 g/mol (Typical average)
Synonyms	Eudragit RL 100; Eudragit RL PO; Poly(ethyl acrylate-co-methyl methacrylate-co-trimethylammonioethyl methacrylate chloride); Ammonio Methacrylate Copolymer, Type A (USP/NF); Cationic Methacrylic Acid Copolymer; Acryl-EZE; Kollicoat EMM 30 D; EUDRAGIT® RL
EINECS	257-390-8

Quality Control

Our Eudragit RL is manufactured and tested to meet stringent pharmaceutical excipient standards. Quality is assured through a comprehensive battery of tests including identification, assay, and impurity profiling. Certificates of Analysis (COA) are provided with each batch, confirming compliance with relevant pharmacopoeial monographs such as USP/NF (Ammonio Methacrylate Copolymer, Type A) and Ph. Eur.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the original container must be kept tightly sealed to prevent moisture uptake, which can affect its flow and processing properties.

Specification

Item	Specification
Appearance	White or off-white free-flowing powder
Identification (IR)	Conforms
Assay (Dry basis)	≥ 98.0 %
Viscosity (20% in acetone)	10 - 25 mPa·s
Residue on Ignition	≤ 0.3 %
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 5.0 %
Quaternary Ammonium Groups	4.5 - 7.0 %
Residual Monomers (GC)	≤ 0.3 % total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.