Description

Hydroxypropyl Methyl Cellulose Acetate Succinate (HPMCAS) is a multifunctional enteric polymer widely used as a key excipient in pharmaceutical formulations. Its primary value lies in its pH-dependent solubility, which enables targeted drug release in the intestinal tract, protecting active ingredients from the acidic gastric environment. This makes it an essential material for manufacturers of solid dosage forms, particularly for enhancing the bioavailability of poorly soluble drugs through amorphous solid dispersions.

Application

• Enteric Coating for Tablets and Capsules: Provides acid resistance for targeted intestinal drug delivery.
• Carrier for Amorphous Solid Dispersions (ASD): Enhances the solubility and bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
• Controlled-Release Matrix Systems: Used in sustained-release formulations to modulate drug dissolution profiles.
• Film-Forming Agent: Applied in coating solutions for pharmaceutical and nutraceutical products.
• Taste Masking: Helps encapsulate bitter-tasting drugs in oral formulations.
• Stabilizer for Suspensions: Improves the physical stability of pharmaceutical suspensions.

Basic Information

Product Name	Hydroxypropyl Methyl Cellulose Acetate Succinate
CAS No.	71138-97-1
Molecular Formula	(C12H20O8)n (Typical base unit)
Molecular Weight	Varies by substitution grade. Contact for details.
Synonyms	HPMCAS; Hypromellose Acetate Succinate; Cellulose, 2-hydroxypropyl methyl ether, acetate succinate; Hydroxypropylmethylcellulose Acetate Succinate; Acetylated Hypromellose Succinate; AQOAT® (Trade Name); Shin-Etsu AQOAT; Enteric Polymer HPMCAS
EINECS	Contact for details.

Quality Control

Our Hydroxypropyl Methyl Cellulose Acetate Succinate is manufactured under strict quality management systems. Each batch is tested against rigorous specifications for pharmaceutical applications, including parameters for acetyl and succinoyl content, viscosity, and pH-dependent dissolution. Certificates of Analysis (COA) are provided with every shipment, and we can support compliance with ICH Q7, GMP, and relevant pharmacopoeial standards (USP/NF, Ph. Eur., JP) as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect performance.

Specification

Item	Specification
Appearance	White to off-white powder or granules
Identification (IR)	Conforms
pH (1% w/v dispersion)	4.0 - 6.0
Viscosity (2% w/v solution)	2.0 - 6.0 mPa·s
Assay (Acetyl Content)	5.0 - 16.0 %
Assay (Succinoyl Content)	4.0 - 28.0 %
Loss on Drying	≤ 5.0 %
Residue on Ignition	≤ 1.0 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.