Description

Cellulose Acetate Phthalate CAS NO 9004-38-0 is a high-performance enteric polymer derived from cellulose, widely recognized for its pH-dependent solubility. This compound is essential for creating protective, gastro-resistant coatings that remain intact in the acidic stomach but dissolve in the higher pH of the intestines. It is a critical material for the pharmaceutical industry, particularly for manufacturers of tablets, capsules, and controlled-release formulations seeking reliable enteric protection.

Application

• Enteric Coating for Solid Dosage Forms: Primary use as a film-forming polymer for tablets and capsules to prevent drug release in the stomach (pH < 5) and ensure targeted delivery in the small intestine.
• Controlled-Release Drug Delivery Systems: A key excipient in matrix systems and multi-layer coatings to achieve delayed or sustained release profiles.
• Protective Barrier for Acid-Labile Drugs: Shields active pharmaceutical ingredients (APIs) that are unstable or irritating to the gastric mucosa.
• Microencapsulation: Used to encapsulate sensitive ingredients, flavors, or probiotics for targeted release in food and nutraceutical applications.
• Specialty Film Formulations: Employed in the development of specialty membranes and films for research and industrial separation processes.

Basic Information

Product Name	Cellulose Acetate Phthalate
CAS No.	9004-38-0
Molecular Formula	(C6H7O2(OCOCH3)x(OCOC6H4COOH)y(OH)3-x-y)n
Molecular Weight	Variable (Polymer)
Synonyms	CAP; Cellacetate; Cellulose Acetate Hydrogen Phthalate; Cellulose Acetate Monophthalate; 1,2-Benzenedicarboxylic Acid, Mono(2-acetyloxy-3-((acetyloxy)methyl)-3,6,9-trioxa-2,10-dioxadodec-11-yl) Ester, Cellulose Deriv.; Acetyl Phthalyl Cellulose; Phthalic Acid Acetate Cellulose Ester; Cellulose Acetate Phthalate Polymer; Enteric Coating Polymer
EINECS	220-336-1

Quality Control

Our Cellulose Acetate Phthalate is manufactured under strict quality systems. It can be supplied to meet various pharmacopoeial standards, including USP-NF and Ph. Eur. specifications for key parameters such as free phthalic acid content, acetyl value, and phthalyl content. Every batch is supported by a comprehensive Certificate of Analysis (COA) to ensure compliance with your formulation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed after opening to prevent moisture uptake, which can affect performance.

Specification

Item	Specification
Appearance	White to off-white free-flowing powder or granules
Identification (IR)	Conforms
Assay (Phthalyl Content)	30.0% - 36.0%
Free Phthalic Acid	≤ 1.0%
Acetyl Value	21.5% - 26.0%
Viscosity (10% solution)	Contact for details
Loss on Drying	≤ 5.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.