Description

Hexamethyldisilazane (HMDS) is a versatile organosilicon compound widely recognized as a premier silylating agent and moisture scavenger. Its primary value lies in its ability to efficiently protect reactive functional groups, such as hydroxyls and amines, by converting them into stable trimethylsilyl derivatives, which is critical for synthesis and analysis. This makes it an indispensable reagent for manufacturers and researchers in the pharmaceutical, semiconductor, and specialty chemical industries.

Application

• Pharmaceutical Synthesis: Used as a protecting agent for hydroxyl and amino groups during the production of active pharmaceutical ingredients (APIs) and intermediates.
• Semiconductor Manufacturing: Serves as a primer and adhesion promoter in photolithography processes for silicon wafer treatment.
• Gas Chromatography (GC): Employed as a derivatization agent to increase the volatility and thermal stability of polar compounds for accurate analysis.
• Polymer & Silicone Chemistry: Acts as a blocking agent and catalyst in the production of silicone polymers and resins.
• Surface Modification: Utilized to hydrophobize surfaces of silica, glass, and other metal oxides for improved material properties.
• Moisture Scavenging: Effectively removes trace water from reaction mixtures and solvents in moisture-sensitive chemical processes.

Basic Information

Product Name	Hexamethyldisilazane
CAS No.	999-97-3
Molecular Formula	C6H19NSi2
Molecular Weight	161.39 g/mol
Synonyms	HMDS; 1,1,1,3,3,3-Hexamethyldisilazane; Bis(trimethylsilyl)amine; Hexamethylsilazane; N,N-Bis(trimethylsilyl)amine; N-(Trimethylsilyl)trimethylsilylamine; Disilazane, 1,1,1,3,3,3-hexamethyl-; NSC 138461
EINECS	213-668-5

Quality Control

Our Hexamethyldisilazane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with the standards required for industrial and technical-grade applications, ensuring reliable performance in your processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and a strong base/organic solvent; keep the container tightly sealed when not in use and away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Chloride (as Cl)	≤ 0.01%
Refractive Index (n20D)	1.407 - 1.409
Density (20°C)	0.774 - 0.778 g/mL
Boiling Point	Approx. 125°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.