Description

L-Methylephedrine Hcl CAS NO 942-46-1 is a high-purity pharmaceutical intermediate and active ingredient, chemically known as (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol hydrochloride. This compound is valued for its precise stereochemistry and consistent quality, which are critical for downstream synthesis and formulation processes. It is primarily utilized by manufacturers in the pharmaceutical, research, and fine chemical sectors for the development of specialized therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of decongestants, bronchodilators, and other adrenergic receptor-targeting active pharmaceutical ingredients (APIs).
• Reference Standard: Serves as a certified reference material (CRM) for quality control, method validation, and regulatory compliance in analytical laboratories.
• Research & Development: Used in preclinical and clinical research for studying pharmacological activity, metabolic pathways, and structure-activity relationships (SAR).
• Fine Chemical Synthesis: Employed in asymmetric synthesis and the production of complex organic molecules requiring specific stereochemical configurations.
• Chemical Standard: Provides a benchmark for identity and purity testing in compliance with pharmacopeial monographs (e.g., USP, EP).

Basic Information

Product Name	L-Methylephedrine Hcl
CAS No.	942-46-1
Molecular Formula	C11H17NO·HCl
Molecular Weight	215.72 g/mol
Synonyms	(-)-Methylephedrine Hydrochloride; L-(-)-Methylephedrine HCl; (1R,2S)-(-)-N-Methylephedrine Hydrochloride; 2-Methylamino-1-phenyl-1-propanol Hydrochloride; Erythro-(-)-2-Methylamino-1-phenylpropan-1-ol Hydrochloride; L-N-Methylephedrine HCl; (1R,2S)-2-(Methylamino)-1-phenylpropan-1-ol Hydrochloride
EINECS	213-386-8

Quality Control

Our L-Methylephedrine HCl is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.