Description

Diisopropylphosphoramidous Dichloride is a highly reactive organophosphorus compound that serves as a critical building block in advanced chemical synthesis. Its value lies in its role as a versatile phosphitylating agent, enabling the efficient introduction of diisopropylphosphoramidite protecting groups. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for oligonucleotide synthesis and the development of novel catalysts and ligands.

Application

• Oligonucleotide and Phosphoramidite Synthesis: A key phosphitylating reagent in the solid-phase synthesis of DNA, RNA, and their analogs.
• Pharmaceutical Intermediates: Used in the preparation of nucleotide prodrugs and other bioactive phosphorus-containing molecules.
• Catalyst and Ligand Preparation: Serves as a precursor for synthesizing chiral phosphoramidite ligands used in asymmetric catalysis.
• Agrochemical Active Ingredients: Intermediate in the synthesis of certain organophosphate insecticides and herbicides.
• Polymer Modification: Employed to introduce phosphorus functional groups into polymers for flame retardancy or other specialized properties.
• Chemical Research & Development: A valuable tool for exploring new P-N and P-O bond formations in academic and industrial R&D settings.

Basic Information

Product Name	Diisopropylphosphoramidous Dichloride
CAS No.	921-26-6
Molecular Formula	C6H15Cl2NOP
Molecular Weight	204.07 g/mol
Synonyms	Diisopropylphosphoramidous Dichloride; Diisopropyl Phosphoramidous Dichloride; Chloro-diisopropylamino-chlorophosphine; Diisopropylaminochlorophosphine; N,N-Diisopropylphosphoramidous Dichloride; Phosphoramidous Dichloride, Diisopropyl-; Diisopropylphosphoramidochloridite; (Diisopropylamino)phosphinous Dichloride
EINECS	Contact for details

Quality Control

Our Diisopropylphosphoramidous Dichloride is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing including NMR, GC, and titration methods to verify identity and assay. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our rigorous internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent decomposition. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.