Description

2-Methylalanine Carboxy-14C Hydrochloride is a carbon-14 labeled derivative of 2-methylalanine, a non-proteinogenic amino acid, where the carboxylic acid group is isotopically enriched. This compound is a crucial tool for metabolic and pharmacokinetic studies, providing a radioactive tracer for precise tracking and quantification in biological systems. It is primarily utilized by researchers and scientists in the pharmaceutical, agrochemical, and life science industries for advanced radiolabeling applications.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled precursor to study the absorption, distribution, metabolism, and excretion (ADME) of novel drug candidates and bioactive compounds.
• Pharmacokinetic Research: Essential for quantifying drug concentrations in plasma and tissues over time to determine bioavailability and half-life.
• Biochemical Mechanism Studies: Employed to investigate specific enzymatic reactions and biosynthetic pathways involving amino acid analogs.
• Agrochemical Development: Applied in environmental fate studies to track the degradation and movement of pesticides or herbicides derived from amino acid structures.
• Protein and Peptide Research: Serves as a building block for synthesizing radiolabeled peptides to study protein-protein interactions and receptor binding.
• Quality Control Reference Standard: Acts as an authenticated standard for analytical method development and validation in regulatory testing.

Basic Information

Product Name	2-Methylalanine Carboxy-14C Hydrochloride
CAS No.	917-98-6
Molecular Formula	C4H9NO2•HCl (with 14C at carboxy position)
Molecular Weight	~139.58 g/mol (unlabeled form)
Synonyms	2-Aminoisobutyric acid-1-14C hydrochloride; (RS)-2-Aminoisobutyric acid-1-14C hydrochloride; 2-Methyl-2-aminopropanoic acid-1-14C hydrochloride; AIB-1-14C hydrochloride; α-Aminoisobutyric acid-1-14C hydrochloride; 2-Aminoisobutanoic acid-1-14C hydrochloride; (±)-2-Aminoisobutyric acid-1-14C hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Methylalanine Carboxy-14C Hydrochloride is manufactured and tested under strict quality systems to ensure traceability and reliability for critical research. We guarantee high radiochemical purity and specific activity, with comprehensive analysis performed via HPLC and radio-HPLC. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, specific activity, and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a controlled environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.