Description

2-Amino-4-(1-Naphthalenyl)-5-Thiazolecarboxylic Acid Ethyl Ester is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel pharmacologically active molecules, particularly within medicinal chemistry research. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and plant growth regulators, leveraging its unique thiazole-naphthalene scaffold.
• Material Science: Investigated as a building block for organic semiconductors, liquid crystals, and fluorescent dyes due to its conjugated aromatic system.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical pathway studies.
• Academic & Institutional Research: Utilized in universities and research institutes for methodological development in heterocyclic chemistry and scaffold diversification studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise molecular architecture.

Basic Information

Product Name	2-Amino-4-(1-Naphthalenyl)-5-Thiazolecarboxylic Acid Ethyl Ester
CAS No.	899363-27-0
Molecular Formula	C₁₆H₁₄N₂O₂S
Molecular Weight	298.36 g/mol
Synonyms	Ethyl 2-Amino-4-(naphthalen-1-yl)thiazole-5-carboxylate; 2-Amino-4-(1-naphthyl)-5-thiazolecarboxylic acid ethyl ester; 4-(1-Naphthyl)-2-amino-5-thiazolecarboxylic acid ethyl ester; 1-Naphthylthiazole derivative; ATCE; NSC 89866; 5-Thiazolecarboxylic acid, 2-amino-4-(1-naphthalenyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our 2-Amino-4-(1-Naphthalenyl)-5-Thiazolecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) documenting all specifications are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.