Description

2-Amino-4-[2-(Trifluoromethyl)Phenyl]-5-Thiazolecarboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block characterized by its thiazole core and trifluoromethylphenyl substituent. This compound matters for its critical role as a sophisticated intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where its unique structure imparts desirable biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Serves as a vital building block for developing new-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Material Science Research: Used in the development of advanced organic materials, including liquid crystals and organic semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	2-Amino-4-[2-(Trifluoromethyl)Phenyl]-5-Thiazolecarboxylic Acid Ethyl Ester
CAS No.	899354-49-5
Molecular Formula	C13H11F3N2O2S
Molecular Weight	316.30 g/mol
Synonyms	Ethyl 2-Amino-4-[2-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylate; 5-Thiazolecarboxylic acid, 2-amino-4-[2-(trifluoromethyl)phenyl]-, ethyl ester; 2-Amino-4-(2-trifluoromethylphenyl)thiazole-5-carboxylic acid ethyl ester; 4-(2-Trifluoromethylphenyl)-2-aminothiazole-5-carboxylic acid ethyl ester; ATFPTE; 899354-49-5
EINECS	Contact for details

Quality Control

Our 2-Amino-4-[2-(Trifluoromethyl)Phenyl]-5-Thiazolecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.