Description

Methyl 5-(6-Methoxynicotinoyl) Thiophene-2-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure combining nicotinoyl and thiophene carboxylate moieties. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Serves as a structural motif in the development of new-generation herbicides and fungicides, leveraging the bioactivity of the thiophene and pyridine rings.
• Material Science: Used in the research and development of organic electronic materials, where its conjugated system can contribute to charge transport properties.
• Academic & R&D: Employed in university and corporate laboratories for methodological studies in heterocyclic chemistry, cross-coupling reactions, and scaffold diversification.
• Contract Synthesis: Supplied to CDMOs for custom synthesis projects and scale-up campaigns under current Good Manufacturing Practice (cGMP) guidelines for pre-clinical and clinical trial material production.

Basic Information

Product Name	Methyl 5-(6-Methoxynicotinoyl) Thiophene-2-Carboxylate
CAS No.	898786-20-4
Molecular Formula	C13H11NO4S
Molecular Weight	277.30 g/mol
Synonyms	Methyl 5-[(6-methoxy-3-pyridinyl)carbonyl]-2-thiophenecarboxylate; 2-Thiophenecarboxylic acid, 5-[(6-methoxy-3-pyridinyl)carbonyl]-, methyl ester; 5-(6-Methoxynicotinoyl)thiophene-2-carboxylic acid methyl ester; Methyl 5-(6-methoxypyridine-3-carbonyl)thiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-(6-Methoxynicotinoyl) Thiophene-2-Carboxylate is manufactured and controlled under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specified parameters are provided with each shipment. We support development and commercial projects with material suitable for research use, non-GMP, or GMP applications, with documentation tailored to your regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.