Description

5-(1,3-Dioxolan-2-Yl)-2-(3,4,5-Trifluorobenzoyl)Thiophene is a high-value, multi-fluorinated heterocyclic building block designed for advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of complex active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to incorporate a unique trifluorobenzoyl-thiophene scaffold into novel molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to the thiophene and fluorinated aromatic systems.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated architecture.

Basic Information

Product Name	5-(1,3-Dioxolan-2-Yl)-2-(3,4,5-Trifluorobenzoyl)Thiophene
CAS No.	898779-34-5
Molecular Formula	C₁₄H₉F₃O₃S
Molecular Weight	314.28 g/mol
Synonyms	2-(3,4,5-Trifluorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene; 5-(1,3-Dioxolan-2-yl)-2-(3,4,5-trifluorobenzoyl)thiophene; 898779-34-5; Thiophene, 5-(1,3-dioxolan-2-yl)-2-(3,4,5-trifluorobenzoyl)-; 2-(3,4,5-Trifluorobenzoyl)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)thiophene (related protected form); TFBT Intermediate; Trifluorobenzoyl Thiophene Derivative
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxolan-2-Yl)-2-(3,4,5-Trifluorobenzoyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.