Description

2-(2,5-Dimethoxybenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is a high-purity, advanced pharmaceutical intermediate characterized by its distinct thiophene-based molecular architecture. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), where its specific functional groups enable precise chemical transformations. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders or possessing complex heterocyclic structures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the exploration of new chemical entities in drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Organic Synthesis Building Block: Employed in academic and industrial laboratories for constructing complex molecules, leveraging its benzoyl and dioxolane-protected aldehyde functionalities.
• Material Science Research: Potential monomer or precursor for the development of specialty polymers or organic electronic materials due to its conjugated thiophene core.

Basic Information

Product Name	2-(2,5-Dimethoxybenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene
CAS No.	898779-04-9
Molecular Formula	C₁₈H₁₈O₅S
Molecular Weight	346.40 g/mol
Synonyms	5-(1,3-Dioxolan-2-yl)-2-(2,5-dimethoxybenzoyl)thiophene; 2-(2,5-Dimethoxybenzoyl)thiophene-5-carboxaldehyde ethylene acetal; Thiophene-5-carboxaldehyde, 2-(2,5-dimethoxybenzoyl)-, ethylene acetal; 898779-04-9; 2,5-Dimethoxybenzoyl thiophene derivative
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dimethoxybenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.