Description

2-(3,4-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is a high-value, multi-functional heterocyclic building block and advanced pharmaceutical intermediate. This compound matters for its precise molecular architecture, which is critical for synthesizing complex active pharmaceutical ingredients (APIs) and agrochemicals with specific biological activity. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new therapeutic agents or crop protection products.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Serves as a core structural component in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluorobenzoyl and thiophene motifs.
• Organic Synthesis Building Block: Used in cross-coupling reactions, functional group transformations, and the construction of complex polycyclic systems in academic and industrial research laboratories.
• Material Science Precursor: Potential intermediate for the synthesis of organic electronic materials, such as semiconductors or light-emitting materials, due to its conjugated thiophene core.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-(3,4-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene
CAS No.	898778-82-0
Molecular Formula	C14H10F2O3S
Molecular Weight	296.29 g/mol
Synonyms	5-(1,3-Dioxolan-2-yl)-2-(3,4-difluorobenzoyl)thiophene; 2-(3,4-Difluorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene; Thiophene, 2-(3,4-difluorobenzoyl)-5-(1,3-dioxolan-2-yl)-; 898778-82-0; 2-(3,4-Difluorobenzoyl)-5-(2,2-dimethyl-1,3-dioxolan-4-yl)thiophene (related); Difluorobenzoyl Thiophene Dioxolane Derivative
EINECS	Contact for details

Quality Control

Our 2-(3,4-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.