Description

2-(2,4-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating thiophene and dioxolane motifs. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated building blocks. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel fluorinated APIs, especially for antiviral, antifungal, and central nervous system (CNS) drugs.
• Agrochemical Research: Serves as a precursor in the development of new-generation herbicides and fungicides with enhanced activity and selectivity.
• Material Science: Used in the research and production of specialty polymers and organic electronic materials due to its conjugated thiophene core.
• Organic Synthesis: A versatile reagent for constructing complex heterocyclic frameworks in academic and industrial R&D laboratories.
• Fluorine Chemistry: An important substrate for studying structure-activity relationships (SAR) in fluorinated compound libraries.

Basic Information

Product Name	2-(2,4-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene
CAS No.	898778-76-2
Molecular Formula	C14H10F2O3S
Molecular Weight	296.29 g/mol
Synonyms	5-(1,3-Dioxolan-2-yl)-2-(2,4-difluorobenzoyl)thiophene; 2-(2,4-Difluorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene; Thiophene, 2-(2,4-difluorobenzoyl)-5-(1,3-dioxolan-2-yl)-; 898778-76-2; Difluorobenzoyl Dioxolanyl Thiophene; DFBDT Intermediate
EINECS	Contact for details

Quality Control

Our production of 2-(2,4-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, open flames, and incompatible materials. The container should be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.