Description

2-(2,3-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is a high-purity, advanced pharmaceutical intermediate characterized by its unique heterocyclic structure incorporating thiophene and dioxolane moieties. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• Organic Synthesis Building Block: Used in research-scale and pilot-scale organic chemistry for constructing novel heterocyclic compounds due to its reactive benzoyl and protected aldehyde (dioxolane) functional groups.
• Agrochemical Research: Serves as a starting material or intermediate in the development of new agrochemicals, where the difluorobenzoyl group can impart specific biological activity.
• Material Science Exploration: Investigated for the development of organic electronic materials, where thiophene derivatives are valued for their conductive properties.
• Academic & Industrial R&D: Employed in method development and discovery chemistry within university laboratories and corporate R&D centers focusing on fluorinated compounds.

Basic Information

Product Name	2-(2,3-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene
CAS No.	898778-73-9
Molecular Formula	C14H10F2O3S
Molecular Weight	296.29 g/mol
Synonyms	5-(1,3-Dioxolan-2-yl)-2-(2,3-difluorobenzoyl)thiophene; 2-(2,3-Difluorobenzoyl)-5-(1,3-dioxolan-2-yl)thiophene; Thiophene, 2-(2,3-difluorobenzoyl)-5-(1,3-dioxolan-2-yl)-; 898778-73-9; 2,3-Difluoro-5'-(1,3-dioxolan-2-yl)-2'-thenylphenylmethanone
EINECS	Contact for details

Quality Control

Our 2-(2,3-Difluorobenzoyl)-5-(1,3-Dioxolan-2-Yl)Thiophene is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (by IR, NMR), and impurity profiles are available for every lot. We support compliance with cGMP and ISO guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.