Description

5-(1,3-Dioxolan-2-Yl)-2-(2-Trifluoromethylbenzoyl)Thiophene is a high-purity, advanced pharmaceutical intermediate characterized by its distinct thiophene and benzophenone-derived structure. This compound is critical for enabling complex synthetic pathways in modern drug discovery and development, offering a versatile building block for creating novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and pharmaceutical manufacturers focused on developing new therapeutic agents, particularly in areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and production of novel drug candidates, especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Research: Serves as a building block for developing new generation pesticides and herbicides, leveraging the biological activity of the thiophene and trifluoromethyl motifs.
• Material Science: Used in the synthesis of specialized organic electronic materials and ligands for catalytic systems due to its conjugated molecular framework.
• Academic & R&D: Essential for methodological studies in organic synthesis, particularly for reactions involving ketone protection (dioxolane) and cross-coupling on thiophene cores.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke synthesis of complex molecules for client projects.

Basic Information

Item	Details
Product Name	5-(1,3-Dioxolan-2-Yl)-2-(2-Trifluoromethylbenzoyl)Thiophene
CAS No.	898773-26-7
Molecular Formula	C₁₅H₁₁F₃O₃S
Molecular Weight	328.31 g/mol
Synonyms	2-(2-Trifluoromethylbenzoyl)-5-(1,3-dioxolan-2-yl)thiophene; 5-(1,3-Dioxolan-2-yl)-2-[(2-trifluoromethyl)benzoyl]thiophene; [5-(1,3-Dioxolan-2-yl)thiophen-2-yl](2-trifluoromethylphenyl)methanone; 898773-26-7; Thiophene, 5-(1,3-dioxolan-2-yl)-2-[(2-trifluoromethylphenyl)carbonyl]-; (2-Trifluoromethylphenyl)[5-(1,3-dioxolan-2-yl)-2-thienyl]methanone
EINECS	Contact for details

Quality Control

Our 5-(1,3-Dioxolan-2-Yl)-2-(2-Trifluoromethylbenzoyl)Thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.