Description

tert-Butyl 5-(1,3-Dioxolan-2-Yl)-2-Thienyl Ketone is a high-purity, specialized organic building block featuring a thiophene core protected by a dioxolane group. This compound is valued for its role as a key synthetic intermediate in the development of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the thiophene moiety for bioactivity.
• Material Science Research: Serves as a building block for creating organic semiconductors, conductive polymers, and other advanced electronic materials due to its conjugated thiophene structure.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and other tools for biochemical research.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	tert-Butyl 5-(1,3-Dioxolan-2-Yl)-2-Thienyl Ketone
CAS No.	898772-82-2
Molecular Formula	C₁₃H₁₈O₃S
Molecular Weight	254.34 g/mol
Synonyms	2-Thiophenecarboxaldehyde, 5-(1,3-dioxolan-2-yl)-, 1,1-dimethylethylhydrazone; 1-(5-(1,3-Dioxolan-2-yl)thiophen-2-yl)-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-[5-(1,3-dioxolan-2-yl)-2-thienyl]-1-propanone; tert-Butyl 5-(1,3-dioxolan-2-yl)thiophene-2-carboxylate (common misnomer); 5-(1,3-Dioxolan-2-yl)-2-thienyl tert-butyl ketone
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(1,3-Dioxolan-2-Yl)-2-Thienyl Ketone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.