Description

3-(3,5-Difluorobenzoyl)Thiophene is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluorobenzoyl-thiophene scaffold imparts desirable biological and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Critical intermediate in the synthesis of pharmaceutical candidates, particularly kinase inhibitors and central nervous system (CNS) active compounds.
• Building block for advanced agrochemicals, including next-generation herbicides and fungicides.
• Precursor in material science for the development of organic semiconductors and electronic materials.
• Key reagent in medicinal chemistry research for structure-activity relationship (SAR) studies and lead optimization.
• Used in custom synthesis and contract manufacturing for specialized fine chemical production.

Basic Information

Product Name	3-(3,5-Difluorobenzoyl)Thiophene
CAS No.	898771-64-7
Molecular Formula	C11H6F2OS
Molecular Weight	224.23 g/mol
Synonyms	3-(3,5-Difluorobenzoyl)thiophene; Thiophene, 3-(3,5-difluorobenzoyl)-; 3,5-Difluorophenyl 3-thienyl ketone; (3,5-Difluorophenyl)(thiophen-3-yl)methanone; 898771-64-7; 3-Thienyl 3,5-difluorophenyl ketone; Methanone, (3,5-difluorophenyl)-3-thienyl-
EINECS	Contact for details

Quality Control

Our 3-(3,5-Difluorobenzoyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.