Description

3-(2,4-Difluorobenzoyl)Thiophene is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and functional materials, where its unique difluorobenzoyl-thiophene scaffold imparts desirable electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated heterocyclic motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and CNS-active compound libraries.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides where the fluorinated aromatic system enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for organic electronic materials, such as semiconductors and light-emitting diodes (OLEDs), due to the electron-accepting nature of the benzoyl group.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis and organocatalysis.
• Custom Synthesis and Contract Manufacturing: Supplied for bespoke chemical synthesis projects requiring high-fidelity fluorinated intermediates.
• Academic and Industrial Research: Utilized in methodological studies and the exploration of new fluorination reactions and heterocyclic chemistry.

Basic Information

Product Name	3-(2,4-Difluorobenzoyl)Thiophene
CAS No.	898771-60-3
Molecular Formula	C11H6F2OS
Molecular Weight	224.23 g/mol
Synonyms	3-(2,4-Difluorobenzoyl)thiophene; 2,4-Difluorophenyl 3-thienyl ketone; 3-(2,4-Difluorobenzoyl)-thiophene; Thiophene-3-carboxylic acid 2,4-difluorophenyl ketone; 1-(2,4-Difluorophenyl)-3-thienylmethanone; 3-(2,4-Difluorobenzoyl)thiophene, 98+%; 898771-60-3; 3-Thienyl 2,4-difluorophenyl ketone
EINECS	Contact for details

Quality Control

Our 3-(2,4-Difluorobenzoyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.