Description

3-(3-Chloro-5-Fluorobenzoyl)Thiophene is a high-purity organic intermediate featuring a benzoylthiophene core structure with strategic halogen substitutions. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical and agrochemical active ingredients. It is primarily needed by R&D chemists and process development scientists in the life sciences sector for creating novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Serves as a building block for developing new-generation herbicides and fungicides, leveraging the bioactivity of the thiophene and fluorinated aryl motifs.
• Material Science Research: Used in the development of organic semiconductors and conductive polymers due to the electron-rich thiophene unit.
• Chemical Biology Probes: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for designing enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP guidelines.

Basic Information

Product Name	3-(3-Chloro-5-Fluorobenzoyl)Thiophene
CAS No.	898771-44-3
Molecular Formula	C11H6ClFOS
Molecular Weight	240.68 g/mol
Synonyms	3-(3-Chloro-5-fluorobenzoyl)thiophene; (3-Chloro-5-fluorophenyl)(thiophen-3-yl)methanone; 3-Chloro-5-fluoro-3-thienyl phenyl ketone; Thiophene-3-carboxylic acid 3-chloro-5-fluorophenyl ester; 898771-44-3; 3-(3-Chloro-5-fluorobenzoyl)thiophene; 3-Chloro-5-fluorobenzoylthiophene
EINECS	Contact for details

Quality Control

Our 3-(3-Chloro-5-Fluorobenzoyl)Thiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to supply chain integrity and regulatory compliance (including REACH) ensures reliable material for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.